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Additionally, its role in diabetes and its complications, such as diabetic nephropathy, retinopathy, cardiomyopathy, and microangiopathy, has been intensively studied [23]

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In addition, the use of AKT inhibitors in combination with extracellular asparagine (ASN) depletion can significantly inhibit tumor growth (Fig

Statements Author contributions GM, LB and AT contributed to develop the theory, to the design and implementation of the research and to the writing of the manuscript

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The authors noted NNMT overexpression in many human malignancies and described 5-Amino-1MQ as a novel NNMT inhibitor with promising results across obesity and cancer cell research models